Фитотерапевт Карп Абрамович Трескунов
Clinical phytology and phytochitodestherapy of autoimmune diseases

Clinical phytology and phytochitodestherapy of autoimmune diseases

Afterhistory (long-tern results)

Academik EANS and RANS, doctor-phytotherapeutist K.A.Treskunov

SCC RAS Chernogolovka, Russia

Autoimmune diseases (AD) such as rheumatoid arthritis (RA), giant cell arthritis (GCA), systemic lupus erythematosus (SLE), dermatosclerosis (DS), dermatomyositis (DM), Hashimoto's thyroiditis (HT), autoimmune thrombocytopenia (AETCP), Wagner's disease (WD), Familial Mediterranean fever (FMF), multiple sclerosis, syringomyelia were described mostly in the second half of the 20 th century. Their etiology is still unknown. It can not be discovered because any specific reason for the disease is absent. Anything that makes worm-blooded animals, birds or humans have inflammation (I), can cause AD. Therefore pathogenesis, development of the disease, is the same for all AD. Essentially it is an inflammation caused by inadequate body's reaction to its own cells, tissues and proteins…

All chronic diseases are autoimmune in some measure. Their development pattern follows a vicious circle. A foreign body such as microbe, virus or fungus invades the cell. Body reaction to this invasion is inflammation, a way to isolate, reject harmful agent that makes the body sacrifice its own tissue. This sacrifice is too high for the body. Modified sphacelus becomes a foreign body itself and causes the body to produce antibodies and develop inflammation. When this process reaches the level of necrosis, necrotic tissue becomes an antigen itself, that causes the body to produce antibodies again, that leads to inflammation. Antibodies and inflammation in their turn destroy this tissue. This is an endless morbific destructive circle. There is no microbe, virus or fungus in the body already, but the disease continues to destroy it.

Discovery of a global value was made since 1972 with the help of hundreds of volunteers [1,2,3,4,5]. According to classical studies inflammation is the main defensive reaction of warm-blooded animals. It is gradual. Unless foreign body is eliminated from the body edema follows hyperemia, then comes infiltration, then necrosis, phagocytosis, pyosis and in the end regeneration process with scarring.

Inflammation lost its defensive role since the second half of the 20 th century, era of antibiotics. Now it is possible to stop this process only by eliminating the reason (etiology), for example microbe, splinter, bullet. And what is the reason of burns or autoimmune diseases? Modern medicine influences the development of AD, influences immunity (Im), but what is the cost? It removes pain or recrudescence at the cost of serious complications, while disease continues to develop. Permanently disabled individuals, high mortality, new serious diseases, new sufferings, disabled children. This is the coast, without mentioning price of medicines and hormones. Sometimes it is necessary to use expensive plastic surgery. The only way to remove strong pain for a short period of time is to use poisonous heavy drugs and glucocorticosteroids. Even gradual chemotherapy withdrawal requires strong patience that is not always possible for seriously ill patients. Aside from stopping any inflammation on any stage phytotherapy and phytochitodes therapy causes regression of inflammation up to complete recovery. It doesn't cause any complications, breaking the vicious circle in its hunting link, and thus leads to “miraculous” recovery.

First database of volunteers, treated using phytotherapy (PT) and phytochitodes therapy (PCT) methods was firstly gathered since 1972 up to present time (2005). Almost all medical plants have anti-inflammatory properties [6,7.8,9,10]. However their effect in different stages of inflammation is different. For example, those plants that contain binding tanning substance s, prevent regression of the inflammation during edema and infiltration stage that in its turn prevents microcirculation. That is why concentration of these plants during abovementioned stages shall be reduced. Therefore during inflammation, hyperemia stage, concentration of binding substances shall be maximally increased. Edema stage requires plants, normalizing microcirculation, and diuretics (dandelion, betula, knot grass, burdock, rib-grass, and horsetail). Infiltration stage requires prevalence of plants-anticoagulants (melilot, spiraea, osier, cobnut, etc.) and those that normalize microcirculation in the twig (burdock, rib-grass, milfoil, melilot, calendula, birch etc.). Stage of necrosis requires prevalence of the plants that stop necrosis, facilitate focalization of purulent lesion and increase regeneration process (burdock, rib-grass, etc.).

Database contains more than 3300 patients, 182 of them suffer from AD (table ¹1). 104 of them or 57% totally recovered (time needed for recovery from 3 months to one year – 16 patients, up to 3 years- 25 patients, up to 5 years – 16 patients, up to 10 years and more - 35 patients). 45 patients (25%) have substantial improvement. No positive take was observed in 26 patients (14%), retrogression was observed in 7 patients (4%). For years all abovementioned patients were examined and treated in rheumatologic centers and clinics of medical universities without any improvement. The best results were observed in patients with SLE, the worst – in patients with rheumatoid arthritis. The explanation for this is that rheumatoid arthritis causes necrosis that frets joint bones too fast and leads to crippling deformities, stiffness and anchylosis .

Table ¹1 Efficiency of phytochitodestherapy in treatment of autoimmune diseases (AD).

Disease

Total number of patients

Before treatment

After treatment

3***

2**

1*

0

1

2

3

Total number of AD

182

117

56

9

104

45

26

7

Rheumatoid arthritis

58

51

6

1

23

18

13

4

Systemic lupus erythematosus

20

20

-

-

13

3

3

1

Giant cell arthritis

3

3

-

-

-

2

-

1

Hashimoto's thyroiditis, panmyelophthisis

24

4

20

-

11

9

3

1

Dermatomyositis

3

2

1

-

2

1

-

-

Autoimmune thrombocytopenia

45

19

19

7

45

-

-

-

Dermatosclerosis

3

2

1

-

-

1

2

-

Nonspecific ulcerative colitis, Grohn's disease, GIT polyposis

12

8

4

-

5

7

-

-

Marie-Striinipell disease, Reiter's syndrome, etc.

14

8

5

1

5

4

5

-

Notes:

*** - severe, ** - medium, * - light, 0 - apparently healthy

Thus PCT is based on treatment of the inflammation. Since 1992 for this treatment we use phytochitodes (PCDD) drugs, invented by our joint work with B.A. Komarov, L. Algulov and L.V. Pogorelskiy. (5,6,7,8].

PCDD consists of dry herbal extract and solvable polyfractional chitosan. Anti-inflammatory tea ¹9 (patented) was used in most cases. The tea consists of: old-man`s- pepper herb, burdock leaves, common nettle leaves, common St. John's wort herb, yellow melilot, wild marjoram, calendula flowers, rose hip, foalfoot and knot grass herb, tormentil and dandelion roots, wild chamomile flowers and horsetail herb.

During the last 5 years we actively used anti-inflammatory tea ¹10 (burdock and rib-grass leave, old-man`s- pepper herb, common St. John's wort and yellow melilot herb, birch leave, common nettle herb, calendula (apex), kilwort and common horsetail herb, knot grass and meadowe geranium herb, dandelion leaves and roots, peppermint leaves, Spanich needles, Glechoma hederacea, and silverweed herbs, French willow, foalfoot and cowberry leaves, red clover flowers). Anti-inflammatory effect of this tea is increased due to the presence of burdock, rib-grass, old-man`s- pepper, calendula, common St. John's wort.

AD treatment shall start from treatment of hormonotherapy complications: gastric and duodenum ulcer, acute gastritis and deudenitis. PCDD 02 series is used for this treatment. This PCDD consists of dry herbal extract (wild chamomile, burdock, mint, old-man`s- pepper herb, common St. John's wort) and solvable polyfractional chitosan –chitodes.

Table ¹2 Phytochitodestherapy (AD)

Complications

Treatment

Total

Intensity before treatment

Intensity after treatment

3***

2**

1*

0

1

2

3

Gastric and duodenum ulcer

PCDD

02 series,

08 series,

04 series

94

24

56

14

29

51

11

3

Acute gastritis

37

20

13

4

25

10

2

-

Acute deudenitis

64

51

11

2

51

11

2

-

Hormonotherapy complications (hypertension, hypercorticalism, osteoporosis)

PCDD

03 series,

09 series,

01 series

88

52

24

12

74

11

3

-

Hormonotherapy complications (mycosis)

PCDD

08 series

54

28

25

1

23

16

10

5

Myocardosis, liver, kidney and pancreas dystrophy

PCDD

P02od series,

OOMS series

139

52

79

8

98

25

13

3

Anemia

PCDD

05 series

63

26

25

12

52

6

3

2

Hemorrhages, blood strokes, sores, petechia

PCDD

09 series

48

22

15

11

41

7

-

-

Notes:

Î –no symptom syndrome

* - mild

** - medium

*** - sever

After liquidation and significant decrease of hormonotherapy and anti-inflammatory treatment complications, we prescribe nostropic treatment with PCDD of 01 and 03 series, 2 tablets 4 times daily sublingually for adults and 1 tablet 4 times daily sublingually for children (can be swallowed with a small amount of water). Hot and cold herbal extract for drinking, II fraction - lotions for skin projection of unhealthy organs, skin wipes, phyto-ointments of herbal extracts and chitosan. Ointment shall be applied to the nose, rectum, vagina, skin projection of unhealthy organs. After repeated scalding of herbal barm it shall not be thrown away but dried on white paper and kept in a glass jar. It is recommended to brew this barm in boiled water, extract it for one hour and pour into the bathtub filed with warm water. Patient shall stay in this bath for 20-30 minutes and without rinsing or rubbing go to warm bed.

PCDD 01 series: chitosan I herbal tea: firetop and ginger plant flowers, birch leaves, killwort and yellow melilot herbs, meadowsweet è cowberry roots and herbs, calendula flowers, wartwort herb, Glechoma hederacea, mugwort and silvery sinquefoil herbs, red raspberry leaves and branches, tormentil roots, red clover flowers, rib-grass and cow-berry leaves, old-man`s- pepper , common St. John's wort, knot grass, bishop`s weed, wild marjoram and Aaron`s beard herbs, burdock roots, wild chamomile flowers, haw berry and cinnamon rose fruits and flowers, blue cow wheat herb, mother`s heart herb, quinquelobate motherwort, lover`s pride herbs, common fumitory herb, yellow bedstraw herb, meadow geranium, common ladies` mantle, common horsetail herbs, common orache and Scotch cotton thistle herbs, dandelion and horseheal roots, Buckthorn Barck, drug speedwell and Veronica chamaedrys herbs, cultivated oat, Spanish needles herbs, heartsease and field violet herbs, common sow thistle herb, worm wood herb, European goldenrod herb, common succory, silverweed, May lily, creeping thyme, brown knapweed , field daisy and tarragon herbs, peppermint leaves, common nettle, black currant leaves, dill seeds, common Scotch pine sprouts, grey alder strobila, creeping wheat and cultivated angelica roots.

PCDD 02 series: chitosan + herbal tea: wild chamomile flowers, peppermint leaves and rib-grass leaves, common St. John's wort and old-man`s- pepper herb.

PCDD 03 series: chitosan - herbal tea: blue cow wheat herb, bishop`s weed, Spanish needles herb, common foaltfoot herb, common Scotch pine sprouts, drug speedwell herb and Glechoma hederacea, common lilac and wool mullein flowers, leaves and branches, wild chamomile flowers, European elder, white dead nettle flowers, yellow melilot herb, common betony herb, creeping thyme, heartsease and field violet herb, common horsetail clown's woundwort herbs, flowers, leaves and branches of Tilia cordata, ginger plant flowers, killwort and cowberry herb, calendula flowers, medicinal fennel fruits, rib-grass leaves, old-man`s- pepper herb , common St. John's wort, silvery sinquefoil, medicinal fennel, wild marjoram, meadow geranium and common ladies` mantle herbs, horseheal root, Geum urbanum roots and rootstocks, peppermint leaves, birch leaves, firetop leaves, common nettle and burdock leaves, knot grass, wartwort, Scotch cotton thistle herb, Dutch myrtle, tarragon and common fumitory herbs, firetop flowers, red clover and European hawthorn flowers, roots of dandelion and burdock, roots and rootstocks of cultivated angelica.

PCDD 04 series: chitosan + herbal tea: knot grass grass, rib-grass leaves, dandelion leaves, common St. John's wort herb, dandelion roots, sweet clover herb, lover's-pride herb, flowers of red clover, common cowberry leaves, peppermint.

PCDD 05 series: chitosan + herbal tea: old-man`s- pepper and common St. John's wort herbs, burdock leaves, rib-grass and birch leaves, knot grass, tormentil roots, ginger plant flowers and wild chamomile flowers, common nettle herb, dandelion roots, yellow melilot and lover's-pride herbs, cinnamon rose fruits, calendula flowers, common sea buckthorn leaves and branches, peppermint leaves, òðàâà medicinal lungwort herb, horseheal roots, wild marjoram herb, common horsetail and Spanish needles herbs, roots and herb of meadowsweet .

PCDD R02od series: chitosan + herbal extract: dandelion roots, peppermint leaves, rib-grass, wild chamomile flowers, common St. John's wort herb and agrimonia eupatoria l. herb.

PCDD 08 series: chitosan + herbal tea: old-man`s- pepper herb, birch leave, mugwort, drug speedwell and heartsease herbs, wartwort, wild chamomile flowers and calendula flowers, ginger plant and red clover flowers.

Clinical cases:

1. Patient B. 29.09.71, fell sick in 1982. The patient was examined and treated in Moscow Institute of clinical rheumatology, where she was diagnosed with systemic lupus erythematosus, chronic lupous glomerulonephritis and myocarditis. For treatment of the disease the patient was given prednisolone 60 mg daily. The following symptoms were present: weakness, fever (up to 38?C), joint pain, back pain, walking dyspnea, insomnia. Erythrocyte sedimentation rate - 66 mm/hour, albuminuria - 4,66 %>, red blood cells up to 15 in sided prism, hyaline casts - 3-6 in sided prism, lupoid factor ++++. Tachycardia, pulse at rest up to 120 per minute. Complications: drug hyperadrenocorticism, hypertension, acute erosive deudenitis, mycotis bronchitis and vulvovaginitis. The patient was put on phototherapy in January 00.01.85, herbal extract of: old-man`s- pepper herb 9 w. p., knot grass 5 w. p., common St. John's wort 3 w. p., common nettle 3 w. p., silverweed 1 w. p., wartwort 3 w. p., heartsease 3 w. p., yellow everlasting 1 w. p., rib-grass leaves 5 w. p., European strawberry 5 w. p, cow-berry 2 w. p, killickinnick 2 w. p, Indian kidney tea 2 w. p, birch sprouts 2 w. p, cinnamon rose fruits 3 w. p, blackberry sprouts 3 w. p, oak bark 1 w. p, Trifolium minus 1 w. p. To brew 1 tablespoon of extract in 0,5 liter of boiled water. To draw for one hour, to filter. To drink 1/3 of a glass 4 times daily 15 minutes before food and before bedtime.

As early as after two weeks the condition of the patient improved significantly, fever disappeared, weakness decreased, back pain and pain in joints disappeared as well. During examination after one month in Moscow Institute of clinical rheumatology: no complaints, normal blood and urine tests, lupoid factor ++. Prednisolon dose was gradually reduced. During examination on 21.03.87 was still drinking phyto-extract. No complaints, normal blood and urine tests, lupoid factor – negative. In 1992 PCDD 09 series was prescribed to the patient in addition to the abovementioned extract. In 1994 the patient delivered a healthy female child. Pregnancy, delivery and postpartum period were without complications. The patient is healthy at present (2005). Her daughter is growing and developing normally. The patient is still using herbal tea and PCDD 09 series.

2. Patient À . 01.08.71 fell sick in January 1993. The patient was examined and treated in Clinic of rheumatism I of I.M. Sechenov Moscow Medical University from systemic lupus erythematosus. The disease was complicated with chronic glomerulonephritis, viral hepatitis  , chronic myocarditis, obstructive bronchitis, high fever of up to 39°, Erythrocyte sedimentation rate up to 80 mm/hour, leucocytosis up to 20*10. Albuminuria1, 66%, hyaline and granular casts 5-6 in sided prism, erythrocytes- 8-10 in sided prism. The patient received high doses of prednisolone (starting from 90 mg) and plaquenil. The treatment was complicated with erosive esophagitis, gastroduodenitis, intestinal hemorrhage, sever chronic hypoferric anemia (hemoglobin up to 75 g\l), thrombocytopenia. Among other symptoms: Itsenko-Cushing syndrome, constant tachycardia, osteoporosis, abdominal pain, walking dyspnea, asthma. 21.06.1993 was brought by her father to our clinic where he asked to treat her daughter with phytotherapy and phytochitodes therapy methods. The patient was treated with extract ¹20 and ¹21, phyto-ointment ¹20 with chitosan (in the nose, rectum, vagina and on the back). Together with herbal extracts the patient was taking phytochitodes 2 tablets 4 times daily 4 of 01 series, 02 series, 03 series, 09 series. Sudden improvement was observed on the sixth day of treatment, joint and abdominal pain disappeared, intestinal hemorrhage stopped, tachycardia and dyspnea decreased, fever and leucocytosis disappeared as well. Weakness, anemia and erythrocyte sedimentation rate decreased gradually. The patient gradually stopped prednisolone and plaquenil. The patient is on phytotherapy and phytochitodes therapy up till now (00.05.05). She got married and delivered a healthy child. 1-2 times per year she is examined in Institute of clinical rheumatology. No signs of SLE are being detected.

3. Patient B., 27.11.55, fell sick in 1990. The patient was frequently treated in the hospitals and clinics of Riazan from bronchial asthma and autoimmune disease with purpura nervosa. Several inhalators and glucocorticoid hormones were used for her treatment. Despite the disease progressed. The patient had two asthmatic attacks daily, she developed chronic bronchitis, pain and hemorrhagic rashes on her lower limbs, chronic nephritis, she was complaining on spasmodic abdominal pain, asthma of physical effort, myocarditis, tachycardia and edema. IgA, IgM, IgG immunoglobulin was significantly increased, erythrocyte sedimentation rate- 44 mm/hour. The patient was put on phytotherapy since 14.10.95; extract ¹100 and ¹ 21, phytochitodes of R02, 03, 08, 10 series. As early as after five days sudden improvement was observed: dyspnea and cough attacks stopped, she stopped using inhalators. Dyspnea, tachycardia, edema and hemorrhagic rashes on her lower limbs disappeared gradually, blood test and gamma globulin started to be within norm. The patient started working. She is on phyto- and phytochitodes therapy up till now.

4. Patient L. 08.04.49, had acute rheumatism, acute rheumatic polyarthritis and acute e ndomyocarditis in 1978. The patient was regularly put on treatment with Bicillinum. During recrudescence of chronic tonsillitis and streptococcus infection in September 1984 patient developed active rheumatism and myocarditis backset. She had cardiac insufficiency, paroxysmal tachycardia edema, dyspnea, cardiac asthma. The patient was treated with the tea of individual extract: haw berry flowers 9 w.p. heartsease herb 7 w.p., horsetail herb, black currant leaves, cinnamon rose fruit, silverweed herb, old-man`s- pepper - 3 w.p., common St. John's wort herb, dandelion roots - 5 w.p., cowberry leaves, killickinnick, maize snout, yellow everlasting herbs - 2 w.p. wild marjoram herb , common nettle - 1 w.p. Since September 1992 the patient started to take phytochitodes of 09+ 04 series 1 hour after breakfast, 10+ 03 series after launch, 09+ 03 series after dinner, 04+ 08 series one hour before bedtime. There were no complaints during examination on 00/07/95, no pathology detected. The patient continues phytotherapy.

Phytotherapy and phytochitodestherapy of rare and sever diseases

¹

Patient

Disease

Main symptoms, syndromes, complications

Beginning of treatment, PCDD series

Recovery – last examination

1

P., 68, fell sick in 1991

GIT and all intestinal track autoimmune disease, pulmanory artery thrombosis;

Intractable diarrhea, sudden loss of weight, hemoconcentration, putrefactive dyspepsia, trombosis of right femoral vein

Since 1991 phyto-extracts and R02, 03 and 08

00.11.02-00.12.03

2

M., 34, fell sick in00.05.93

Systemic lupus erythematosus (SLE)

Chronic necrotic nephritis,

albuminuria, albumin 3,3 %, haematuria, kidney insufficiency, erythrocyte sedimentation rate 60 mm/hour, Cushing (prednisolone, cytostatic)

Since 08.2001 phyto-extracts 01,03, 10, 52, 54

10.2001-16.10.2003

3

B., 48, fell sick in 1994

Panmyelophthisis

Hemorrhages, ulcerative stomatitis, anemia, leukopenia, thrombocytopenia, was living on periodic blood transfusion

Since 00.03.96 05 and phyto-extracts

00.06.96-00.06.02

4

K., 29, fell sick in 1990

Systemic lupus erythematosus (SLE)

Lupus dermatitis, polyarthritis, cardiacangina, mild myocardial infarction, chronic hepatosis, posttraumatic encephalopathy, cardiac insufficiency, dyspnea attacks, chronic pyelonephritis, surgery coronary artery bypass graft, denolymphitis

Since 31.07.01 phyto-extracts 04A and 03

00.06.02-00.03.04

5

Sh., 27. fell sick in 1996

Systemic lupus erythematosus (SLE)

Polyarthralgia, «butterfly», Raynaud's syndrome, chronic nephritis, erythrocyturia, cylindruria, «lupus cells», fever, weakness

Since 06.11.00

phyto-extracts 03

00.04.01-00.10.01

6

B., 14, fell sick in 1982

Systemic lupus erythematosus (SLE)

Chronic nephritis, chronic myocarditis, fever, weakness, joint pain, «butterfly», albuminuria, erythrocyturia, erythrocyte sedimentation rate 50 mm/hour, tachycardia, mycosis.

Since 06.01.85 phyto-extracts 04, 09

00.03.87-00.0.02

7

Sh., 25,

Thrombocytopenic purpura

Sores, uterine bleedings, spleen removed, hypochromic anemia, nasal bleeding, thrombocytopenia

Since 05.12.01 phyto-extracts 05, 09

10.01.02-00.01.05

Deepest thanks for help in working on this article to O.K. Shirokova, B. À . Komarov, À .V. Goroshetchenko, N.V. Komarova, U.E. Ignatev, Ì .V. Stepanova.

List of references:

Treskunov Ê . À . Phitotherapy of autoimmune diseases // Bud zdorov! - 2000 - ¹9 —P. 14-20.

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